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KMID : 0960920020010020127
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Dementia and Neurocognitive Disorders
2002 Volume.1 No. 2 p.127 ~ p.132
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A Patient of Progressive Nonfluent Aphasia with Gradual Development of Memory and Cognitive Impairment
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Kim Chan-Sok
Park Mee-Young
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Abstract
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Progressive nonfluent aphasia is a subtype of frontotemporal lobe degeneration characterized by anomia and word finding difficulty with effortful speech production, phonologic and grammatical errors, and word retrieval difficulties but intact
semantic comprehension. The disorder of language occurs in the absence of impairment in other cognitive domains, although behavioral changes of frontotemporal dementia may emerge late in the disease course. Because there were few reports that described the course of the progressive nonfluent aphasia until the full expression of the disease, were report a case of progressive nonfluent aphasia that has lately shown memory and cognitive disturbances without noticeable personality or behavior change over the following two years. Initial Brain MRI showed cerebral cortical atrophy around the left Sylvian fissure, including left frontal lobe and the superior temporal gyrus. Brain SPECT demonstrated moderate hypoperfusion in the left frontal cortex. But repeated brain MRI scans showed severe left medial temporal atrophy with more severely progressed left perisylvian, frontotemporal atophy and bilateral frontal and medial temporal cortical involvement. Concurrently performed brain SPECT demonstrated more profound hypoperfusion than the initial study did. This was detected not only in the frontal, but also in the medial temporal lobes, predominantly on the left side.
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KEYWORD
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Progressive nonfluent aphasia, Frontotemporal dementia, Memory and cognitive impairment
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